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Concordance of programmed death-ligand 1 expression between primary and metastatic non-small cell lung cancer by immunohistochemistry and RNA in situ hybridization

PMID 22089317

AC: Writing review and editing, Visualization

Figure 2 IGF-1, SIRT1, and FOXO1 in Osteosarcoma In osteosarcoma, increased levels of IGF-1 and IGF-1R have been found that seem to lead to tumor progression through transformation, proliferation, decreased susceptibility to apoptosis, and a phenotype prone to metastasis, including increase cell motility, invasion, and angiogenesis (109111)

The complexity of these regulatory networks underscores the need for combination therapies that simultaneously target multiple nodes in the ferroptosis pathway for optimal therapeutic efficacy against this aggressive brain tumor