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In addition, high levels of leptin, hypothalamicpituitaryadrenal axis activity, obstructive sleep apnea, and baroreflex issues contribute to sympathetic nervous system activation in MetS (140)

Pretreatment of HK2 cells with SFN protected against hypoxiareoxygenation-induced cytotoxicity in a dose-dependent manner, and significantly augmented mRNA expression of phase 2 enzymes [118]

Doxepin rinse versus placebo in the treatment of acute oral mucositis pain in patients receiving head and neck radiotherapy with or without chemotherapy: a phase III, randomized, double-blind trial (NCCTG-N09C6 [Alliance])

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