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Carbajal R, Rousset A, Danan C et al , Epidemiology and treatment of painful procedures in neonates in intensive care units

These substances can be also produced by basophils, eosinophils, and macrophages under the influence of cytokines secreted by Th2 (IL-3, IL-4, IL-5, IL-13, GM-CSF) (182, 183)

This is particularly relevant for these drugs, as they are functioning by increasing GH, which rises and falls in spikes that cant be cleanly predicted from the dose itself