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Quick Takeaways Clinical trials demonstrate safe, sustained efficacy for up to 52 weeks of continuous Tesamorelin use at 2 mg daily in HIV populations My recommended protocol: 5 days on, 2 days off weekly, with 8-week cycles followed by 8 weeks off Cycling is the smart approach to minimize antibody formation and maintain receptor sensitivity over the long haul Visceral fat reductions can reverse upon cessation, which is why lifestyle optimization MUST accompany any Tesamorelin protocol What Tesamorelin Actually Does (And Why Cycle Length Matters) Most people using Tesamorelin have no idea how it works from a mechanistic standpoint