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Long-term body composition and metabolic changes in antiretroviral naive persons randomized to protease inhibitor-, nonnucleoside reverse transcriptase inhibitor-, or protease inhibitor plus nonnucleoside reverse transcriptase inhibitor-based strategy

The ratio of reduced glutathione to glutathione disulfide has been shown to be critical in cell survival, this system is very tightly regulated

doi: 10.3390/nu16060778 115

Importantly, protein levels of GCLC followed the trend observed with Nrf2 protein: GCLC levels were elevated by NFT treatment, and anti Nrf2-siRNA largely prevented this increase (Fig