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This has been observed in clinical practice where 34% of patients co-prescribed metformin alongside PPIs were vitamin B 12 deficient, significantly greater than those on metformin (22%) or PPIs (26%) monotherapy, suggesting an additive effect

In order to identify nutritional triggers, experts suggest the use of food diaries because they are simple, inexpensive, and removal of trigger foods is associated with a reduction in migraine headaches (Sun-Edelstein 2009a)

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Combined peptide interaction studies may provide insight into connective tissue organization and structural recovery mechanisms

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