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10.1016/j.ghir.2004.02.001

When stimulated by oxidative stress or Nrf2 activators, the thiol groups on cysteine residues in Keap1 are modified by electrophiles, and the function of Keap1 is diminished, ultimately resulting in the dissociation of Nrf2 from Keap1 and activation of Nrf2 and ARE genes (Hayes et al., 2010)