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S2CID 25475434

Tat upregulates lncRNA Xist, which sponges miR-124, leading to CCL2 overexpression and microglial activation [147]

First , the overall AF/AFL burden associated with lead exposure has increased substantially over the past three decades, in parallel with the growing global incidence of AF/AFL ( Our findings suggest that lead exposure is an under-recognized yet important contributor to AF/AFL burden, acting through multiple direct and indirect mechanisms