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All experimental procedures were reviewed and approved by regional Institutional Animal Care and Use Committees (IACUC) and performed in accordance with national and international laws and policies (EU Directive 2010/63/EU)

For example, CDK4/6 inhibitors have been shown to delay disease progression in hormone receptor-positive (HR+) breast cancer 20

The current findings are in line with Wolkowitz et al

Meanwhile, use in more common neurological conditionssuch as migraine and Parkinsons diseasehas been driven largely by empirical efficacy and mechanistic inference, with standardized outcome metrics and controlled trials still lacking (3)

Therefore, novel therapy approaches and agents are critical in the treatment of triple-negative breast cancers and metastasis