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Cardiovasc Toxicol 17(2):109119

stems provides new insights for genotype discrimination and polyphenol metabolism structuring

Gliotoxin suppresses hippocampal neurotrophic factors, and the systemic inflammatory burden reduces cerebral blood flow to the prefrontal cortex and hippocampus areas critical for encoding and retrieving short-term memories

Representative mutations are those that interfere with contact points between the and subunits (e.g., Hb Philly [ 35TyrPhe ]), alter the helical segments (e.g., Hb Genova [ 28LeuPro ]), or disrupt interactions of the hydrophobic pockets of the globin subunits with heme (e.g., Hb Kln [ 98ValMet ]) (Table 127-3)

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