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When reconstituting lyophilized peptides above 50mg, a higher volume of bacteriostatic water may be needed

Lv Z, Che L, Du Y, Yu J, Su E, Liu H, et al

Nucleic Acids Res 38:57185734

In summary, the core challenges impeding PROTAC clinical translation are intrinsic to their molecular architecture: unfavorable physicochemical properties engender poor permeability, formulation difficulties, and nonspecific biodistribution