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Early diagnosis and initiation of treatment are essential to ensure success (44)

392,393 Iron accumulates in the parenchymal cells of various organs in HH patients, generating ROS through the Fenton reaction, resulting in ferroptosis and several serious chronic complications, including heart disease, diabetes, and cirrhosis

without a sufficient supply of cysteine, the entire glutathione synthesis pathway grinds to a halt, leaving cells vulnerable to oxidative damage

Penn D, Ludwigs B, Schmidt-Sommerfeld E, Pascu F

169 Despite initial investigations into drugs based on the tau hypothesis not yielding promising results, 152 numerous treatments are still actively being developed