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Over the past 15 years more than 400 clinical trials of drugs to treat AD have been conducted [29]

VEGFR2 may be involved in endothelial cell development, proliferation, and lifespan (5)

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Since SK channels were involved in changes of NO and ROS generation in presence of epinephrine and D1/D5 agonists and they contribute also to regulation of membrane potential, the influence of membrane potential on ROS generation was investigated