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While SSRIs are efficacious, their safety profile in terms of reproductive system toxicity remains controversial, especially in developing adolescents, fertile adults, and perinatal pregnant women ( 2 Effects of SSRIs on reproductive cytogenesis 2.1 Effects of SSRIs on male germ cells Several studies have found that fluoxetine disrupts the hypothalamuslobetestis axis, significantly decreasing the serum concentrations of luteinizing hormone (LH), follicle stimulating hormone (FSH), progesterone, and testosterone, while also affecting several sperm quality parameters, as evidenced by decreased sperm concentrations and viability, increased deoxyribonucleic acid (DNA) fragmentation, and lower reproductive organ weights (Figure 1), which could have been attributed to diminished androgen levels

Thus, this study firstly added an insight that semaglutide can favourably affect more clinically important renal endpoints in patients with type 2 diabetes and CKD

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Scientific Significance and Potential Implications MOTS-c represents a novel mechanism of mitochondrial-to-nuclear signaling

I find that idea interesting because it fits with the broader concept of signaling