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AOD-9604 failed Phase 2 not due to safety concerns but because the magnitude of fat loss versus placebo, while statistically significant, was too modest to meet the efficacy threshold for a standalone obesity treatment

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(ii) inhibiting the generation of transforming growth factor beta, which prevents premature conversion of hair follicles from the anagen to the regressive phase [[23], [24], [25], [26]]

The concentration of unbound IGF-I in the circulation is likely to be proportional to unbound IGF-I concentrations in the tissues, but they are not equal and may have different relationship in different target tissues with differentially-expressed IGFBPs

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