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Mitochondrial superoxide: A key player in Alzheimers disease

doi: 10.3390/cells13181555 240 TamburiniBDi LibertoDPratelliGRizzoCBarberaLLLauricellaMet al

First, a significant portion of the mechanistic data stems from preclinical animal models, which, while informative, cannot fully capture the complexity of human aging

[171] emphasize caffeines inhibitory effects on pKr-2, a protein upregulated during BBB disruption, which drives hippocampal neuroinflammation and neurodegeneration