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3,4 As the disease progresses, retinal pigment epithelium (RPE) cells gradually degenerate and lead to the death of photoreceptor cells around the macula

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This leads to the downregulation of VSMC markers and activation of an OBs program, resulting in increased expression of Runx2 and osteocalcin, as well as enhanced alkaline phosphatase activity, ultimately leading to VSMC calcification [200]

It also suppressed TGF- activation and inflammatory cytokines, thereby resulting in the breakdown of the ECM accumulation pathway [58]

Yamaguchi & H