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The N-surface in these domains often contains more conserved residues than those in the other surfaces, and is the membrane-binding surface for most BAR, F-BAR and I-BAR domains 23

The aggregation of A and hyperphosphorylated tau, as well as neuroinflammation and synaptic dysfunction driven by ApoE, collectively contribute to progressive neurodegeneration (Yamazaki et al., 2019)