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(PubMed) Bertoia M, Albanes D, Mayne ST, Mannisto S, Virtamo J, Wright ME

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Upon zinc depletion, SOD1 mutants underwent conformational changes due to zinc dissociation, which resulted in oxidative stress and endoplasmic reticulum (ER) stress 25

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Thus, the inhibitors of histone deacetylation or demethylation may be promising agents for MS treatment

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