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Indeed, in experimental animal models, the overexpression of CTGF alone leads only to mild fibrosis [98,99,100,101,102]

Oxidative stress is one of the most important mechanisms of increased cellular senescence and frailty, leading to a wide range of diseases that are common in the older population, including chronic lung disease, cardiovascular disease, chronic kidney disease, skeletal muscle dysfunction and cancer (188, 189)

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If you do feel anything unusual, such as temporary fatigue for a day or two, which can happen but is rare, stop using, and email [email protected]