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Furthermore, we uncover dysregulation of the metabolic enzymes phosphate-activated glutaminase (PAG) and glutamate dehydrogenase human isoform 2 (GDH2), crucial regulators in brain glutamate-glutamine homeostasis, in FTD3 pathogenesis

, Chen E

While SCFA levels showed a modest, non-significant decrease during the demyelination, they rebounded in the remyelination phase, significantly so for butyrate (p = 0.0300) and propionate (p = 0.0256)