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Reduced metabotropic glutamate receptor 5 density in major depression determined by [(11)C]ABP688 PET and postmortem study

(PubMed) Pineda M, Montero R, Aracil A, et al

doi: 10.3389/fimmu.2021.750753 6

As some of these could be potential target of the accumulating 5-OP we evaluated deletions of these strains for any alterations in 5-OP toxicity (Fig 2C) and a few in liquid cultures (Fig S6)

1 This ground-breaking study showed that the gene therapy cell product (betibeglogene autotemcel or beti-cel) led to transfusion independence in most treated patients (16/18, 89%), all of whom had genotypes that are associated with severe -thalassemia (i.e., 0 / 0 , 0 / IVS1-110 , IVS1-110 / IVS1-110 )