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First, accumulating evidence has shown that the expression and function of key efferocytosis receptors, MerTK (183), LRP1 (184), and SR-BI (185) are impaired in advanced atherosclerosis

However, there are several avenues of research that may help mitigate these side effects while successfully downregulating immunosuppressive pathways

The vascular phenotype of the conditional deletion was milder than that of the germ line deletion (Fig 2A and B), likely due to delayed onset of the loss of Gpr124 function after tamoxifen injection

The authors also acknowledge financial support from UGC-CAS doctoral fellowship (to P.P.), DST-INSPIRE fellowship (to O.M.) and CSIR-Junior research fellowship (to A.B.)

Wang L, Ahn YJ, Asmis R