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( a - d ) Observed mean percentage change from baseline over time for participants in the full analysis set during the in-trial observation period in waist circumference (a), systolic blood pressure (b), diastolic blood pressure (c), and HbA 1c (d)

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The size distribution was between 50 and 90 nm in diameter

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This multi-pathway profile partly explains the breadth of biological effects observed across diverse preclinical models