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10.1016/s0735-1097(00)00798-1 21 KoethR

PICO, PICOS and SPIDER: A comparison study of specificity and sensitivity in three search tools for qualitative systematic reviews

Contribution of Trimethylamine N-Oxide (TMAO) to Chronic Inflammatory and Degenerative Diseases

and 25 patients received a combination of acetyl-l-carnitine at a dose used in arm A plus low-dose, i.e., 150 mg/day, pregabalin (arm C) for 8 weeks and were subsequently observed for an additional 8 weeks to assess relapse latency and frequency

A potential benefit of L-carnitine in these patients is based on the fact that it can (i) increase the oxidation of long-chain fatty acids which accumulation may contribute to insulin resistance in skeletal muscle, and (ii) enhance glucose utilization by reducing acyl-CoA concentration within the mitochondrial matrix (see Biological Activities) (42)