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The 2-methylquinazoline derivative F7, a compound that selectively inhibits HDAC6, can significantly alleviate the dilation, swelling, necrosis, and tubular formation of renal tubules and improve acute renal insufficiency in glycerol-induced rhabdomyolysis AKI mouse model and the HK-2 cells treated with ferrous myoglobin

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Effects of Solar Radiation on the Eyes

Kang W, Tian Y, Zhao Y, Yin X, Teng Z

When the antioxidant system cant withstand iron overload, excessive ROS will attack sensitive fatty acids, trigger peroxidation, destroy the integrity of cell membrane, increase oxidative stress in vivo , and destroy DNA, protein and lipids, thus aggravating lipid metabolism disorder and further causing ferroptosis ( 1.2.2 NADPH-FSP1-CoQ10 pathway NADPH-FSP1-CoQ10 pathway is another key anti-ferroptosis pathway