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Firstly, given the heterogeneous nature of cellular senescence, characterizing senescent cells based on single molecular marker may not reflect the exact condition of senescent cell accumulation in vivo

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Under hypoxic conditions, reactive oxygen species can accumulate and cause additional activation of HIF1-, and thereby trigger various processes related to tumor progression, such as angiogenesis via expression of e.g., VEGFs and their receptors VEGFR1/2 (7880)

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