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Cochran, H.S

Its working mechanism is allosteric facilitation of HGF/c-Met signaling: Dihexa binds HGF with high affinity (reported K d ~65 pM in the original work) and is proposed to potentiate HGF dimerization and c-Met phosphorylation at subthreshold endogenous HGF concentrations

Therapy using agonist medication is linked with an estimated death reduction of approximately 50 percent among individuals with opioid addiction

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Generally, these new strategies should be directed towards diseases with significant unmet clinical needs, including cases that have relapsed or are resistant to current treatments, as well as rare (orphan) diseases