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officinale has been widely utilized in food as spices, flavoring agents and health supplements and widely used in traditional Chinese medicine (TCM), Ayurveda, and traditional Greco-Arab and Islamic medicine (Saad, 2022)

In the beginning, microglia interact with cerebral blood vessels to preserve the integrity of the BBB

Additionally, a pilot study in 10 women (ages 40 years or older) with noticeable photodamage and solar lentigines found that twice daily topical application of a gel containing 0.66% SCC complex salts for eight weeks improved various clinical measures, including tactile and visual roughness of facial skin, skin radiance, fine lines, pore size, and overall photodamage (46)

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Therefore, disruptions in PLP synthesis in a person with MTHFR variations may lead to issues with amino acid metabolism, homocysteine levels, and neurotransmitter synthesis, as well as glycogenolysis