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(2017, March)

The following agents were used as positive controls: cytomix (known inflammatory-inducing agent, prepared using 500 ng/mL TNF-, 0.2 mg/mL lipopolysaccharide, 1% FCS, tissue exposure via liquid basal), Triton X-100 (cytotoxic at 10%, via liquid basal exposure) or IL-13 (a goblet cell hyper-, metaplasia agent at 10 ng/mL, via liquid basal exposure)

The meta-analysis of these three randomized, double-blind, placebo-controlled trials found no effect of L-carnitine (0.25-4 g/day for 1 week to 3 months) or ALCAR (3 g/day for 6 months) on the level of cancer-related fatigue (108)

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In vivo correction of COX deficiency by activation of the AMPK/PGC-1 axis