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Jaeschke H, McGill MR, Ramachandran A

A mitochondria-targeted covalent organic framework (COF) prodrug that is selectively activated by high intramitochondrial GSH levels was shown to trigger catalase collapse within the organelle, thereby amplifying local chemodynamic therapy (CDT) through enhanced ROS accumulation and mitochondrial dysfunction

It has the highest mortality rate compared to other skin tumors, such as basal cell carcinoma and cutaneous squamous cell carcinoma (223, 224)

Screening for and treating low iron is a key part of managing heart failure

Glutathione upregulates the NOS pathway and protects NO from oxidative reaction