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The same paper is refreshingly candid about the gaps: key questions like ideal treatment duration, how long any effect lasts, and maintenance dosing were still unanswered as of publication

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[25] The AT:P IIA and AT:P IID complexes are allosterically regulated in a reciprocal fashion by -ketoglutarate (-KG) and glutamine (Gln)

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With this aim in mind, a disruptor (PZIF67-AT) based on the modification of an inhibitor (3-amino-1,2,4, triazole) and poly(ethylene glycol) on zeolitic imidazole framework nanoparticles bridged by 2-methylimidazole and cobalt ions was prepared (Sang et al