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This dysfunction occurs at the central level, involving the brain, and the peripheral level, involving non-spinal nerves throughout the body, and may be aggravated by crosstalk between the nervous system and immune cells

252 Oxidized low-density lipoproteins (oxLDL) are injurious to DRG neurons and vascular endothelial cells, contributing to neuronal damage and microvascular dysfunction

doi: 10.1200/JCO.2016.72.1316 57 WolchokJDChiarion-SileniVGonzalezRRutkowskiPGrobJ-JCoweyCLet al

The evidence base for this blend is preclinical and indirect

Avoid alcohol and anti-inflammatory medications (aspirin, ibuprofen) to reduce the risk of bruising only if safe for you to stop