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Drapier S, Eusebio A, Degos B, Vrin M, Durif F, Azulay JP, et al

Glutathione synthesis in your brain follows the same pathway as in the rest of your body

Injection of mitochondrial toxin (3-nitropropionic acid (3-NP)) in transgenic mice with partial deficiency of SOD2 (heterozygous SOD2-knockout) induced significantly larger striatal lesions, proving the fact that SOD play an imminent role in neurotoxicity studies of HD (Andreassen et al., 2001, Chidambaram et al., 2017)

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Therefore, ferroptosis may be the primary pathway through which ischemia-reperfusion injury triggers AKI