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While immune and neuroinflammatory responses are protective against infection and injury, excessive activity in these pathways can damage normal tissues, leading to inflammatory injury of dopaminergic neurons and driving PD progression ( In MPTP-induced PD mouse models, astragaloside IV (AS-IV), the primary active component of Astragalus membranaceus (Fisch.), administered at doses of 1.5, 3, and 6 mg/kg for 10 days, demonstrated dose-dependent improvements in motor dysfunction

Acknowledgements The authors are grateful to U