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Depression and fatigue Supports energy metabolism and neurotransmitter function

The subsequent increase in metabolic rate leads to a reduction in white adipose tissue and has been shown to produce significant weight loss in preclinical studies without affecting appetite

Patients often report feeling less irritable or anxious, and even finding relief from symptoms of depression linked to their deficiency

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A summary of possible NAD + metabolite fluxes in the human body based on the mice studies summarized below is proposed in Fig