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Neurodegenerative diseases have been linked to microglia hyperactivation, and in vitro cultures, IL-10 has been demonstrated to prevent microglia and other glia from producing proinflammatory cytokines [38]

In silico analysis of the genes flanking copR revealed putative CopR-binding cop box sequences in the promoter region of the adjacent gene copB encoding a Cu 2+ -exporting ATPase