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Consistently, KGA-WT overexpression significantly reduced the elevated levels of lipid ROS triggered by KGA interference, whereas KGA-MUT alone did not offer such an effect (Fig

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Luo H, Wang X, Wang J, Chen C, Wang N, Xu Z, et al

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In particular, brain organoids are revolutionizing the study of mitochondrial-based neurological diseases since they are organ-specific and model-generated from a patients cell, thereby overcoming some of the limitations of traditional animal and cell models