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Ca 2+ dependent desensitization of TRPV2 channels is mediated by hydrolysis of phosphatidylinositol 4,5-bisphosphate

Furthermore, the copper transporter ATP7A has been identified as a novel ferroptosis regulator, as its deficiency downregulates the cystine transporter SLC7A11, impairing GSH synthesis and sensitizing cells to ferroptosis [72]

At excitatory synapses, GSK3 phosphorylates PSD95 and modulates excitatory synaptic plasticity in an N-Methyl-D-Aspartate (NMDA) receptor-dependent manner by inducing -Amino-3-hydroxy- 5-Methyl-4-isoxazolepropionic acid (AMPA) receptor internalization and thus LTD (Nelson et al., 2013) while ERKs boost excitatory synaptic and structural plasticity at different levels (Zhu et al., 2002

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