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Mutations in both proB and proA , the first two genes in L-proline biosynthesis, provided a new pathway for -glutamyl cysteine formation via the selective interception of ProB-bound -glutamyl phosphate by amino acid thiols, likely through an S-to-N acyl shift mechanism

Glutathione, a naturally occurring antioxidant with many physiologic functions, can quickly resolve vocal cord polyps and may have a role in the management of other respiratory tract disorders, according to Benjamin Asher, MD, a New York City based Ear, Nose & Throat specialist

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Notably, the baseline augmented synthesis of TTP nucleotide and GSH in HIF1 KO cells compared to HIF WT and HIF2 KO NSCLC cells aligns with their more radioresistant phenotype [34]

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