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Higher concentrations of carnitine were seen in the upper quartiles of TMAO.9 A 2017 systemic review and meta-analysis found that high TMAO levels were a much stronger predictor of cardiovascular events than were elevated levels of its nutrient precursors, including carnitine, regardless of conventional CVD risk factors.10 To investigate whether circulating L-carnitine is related to the risk of incident coronary heart disease (CHD) in apparently healthy people at normal risk, A 2022 prospective nested case-control study looked at associations between CVD risk and 10-year changes in plasma L-carnitine levels in 772 women enrolled in the Nurses Health Study

Multiple studies have demonstrated a significant reduction in beneficial SCFAs-producing bacteria in PCOS patients, such as Butyricicoccus , Blautia , Coprococcus , Faecalibacterium prausnitzii , the Clostridium innocuum group , and Prevotella , leading to decreased intestinal SCFAs levels ( Figure 1 )

Aresti Sanz, J

doi: 10.1016/j.jjcc.2017.02.006 57