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431 Cellular senescence is associated with a range of non-proliferative conditions, including lung fibrosis, kidney diseases, liver steatosis, metabolic syndrome related to obesity, type I and II diabetes, atherosclerosis, and neurodegenerative diseases such as Alzheimers and Parkinsons disease

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Atherosclerotic plaque production in both mice and humans localizes to discrete regions of the vascular tree that experience alterations in blood flow, such as vessel curvatures, branch points, and bifurcations [12]