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l-Citrulline Supplementation: Impact on Cardiometabolic Health

The pathogenesis of myelodysplastic syndrome (MDS) and erythropoiesis involve PLC-1/protein kinase C (PKC) signal transduction, especially nuclear PLC-1 gene (94).PLC-1a is a negative regulator of erythroid differentiation, and which is reduced in erythropoietin-responder MDS patients and in normal hematopoietic stem cell progenitors induced to erythroid differentiation (95)

More serious side effects include temporary or permanent nerve damage or numbness when too much energy is applied

Conclusion and perspectives Lactylation has emerged as a multifaceted regulatory mechanism that not only modulates gene transcription and signal transduction but also profoundly influences protein characteristics and functions