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Whereas CB2R agonists in cAMP assays result in a decreased signal, CB2R-dependent -arrestin recruitment results in a gain-of-signal that requires up to 100% receptor occupancy for a maximal effect

Epithelial cell adhesion molecule (EpCAM) is involved in prostate cancer chemotherapy/radiotherapy response in vivo

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GLP-1 Receptor Activation: Suppresses appetite through hypothalamic pathways Slows gastric emptying Enhances insulin secretion GIP Receptor Activation: Amplifies GLP-1 satiety effects Improves insulin sensitivity May directly affect fat cell metabolism Glucagon Receptor Activation: Increases energy expenditure (metabolic rate) Promotes fat breakdown (lipolysis) May prevent metabolic adaptation The Advantage: Single molecule means simpler manufacturing, potentially easier regulatory approval, and all three pathways activated with every dose

Ianiro G, Porcari S, Settanni CR, et al