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340 Additionally, it is of great importance to note that ZIP7 plays a vital role in ferroptosis, which may establish a connection between ferroptosis susceptibility and treatment-resistant cells, as described in reference

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2023 Jan 17;4(1):100895

Additionally, pattern recognition receptors like TLR2 and TLR4 on microglia can be chronically stimulated or desensitized by repetitive exposure to microbial MAMPs translocating from the gut, potentially affecting how microglia respond to misfolded proteins (either by over-reacting and causing bystander damage, or by entering a tolerant state that might impair clearance of aggregates) [71, 119]

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