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Design, synthesis, and biological evaluation of first-in-class indomethacin-based PROTACs degrading SARS-CoV-2 main protease and with broad-spectrum antiviral activity

Cell Cycle 19 , 30543065 (2020)

It is of great significance to investigate the involvement of disordered iron homeostasis in the imbalanced metabolism of glucose, lipids, and amino acids, as this leads to impaired energy production and ferroptosis

In order to improve the tissue responsivity to insulin, a fasting protocol has been introduced to experimental mice, which is giving access to food for only 5 out of 7 days of the week (75)