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A meta-analysis published in Sleep Medicine Reviews indicates that individuals who experience chronic sleep deprivation are at a higher risk for developing conditions such as obesity, diabetes, and cardiovascular diseases

Osteoarthritis Cartilage 22:17741783 Buckwalter JA, Mankin HJ (1998) Articular cartilage: degeneration and osteoarthritis, repair, regeneration, and transplantation

Excitation-inhibition imbalance leads to alteration of neuronal coherence and neurovascular coupling under acute stress

Women have lower cortisol levels and effects, and lower cortisol responses to stress than men (276283)

This in turn leads to excessive free radical formation