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CO 2 is a potent regulator of CBF, as elevated CO 2 and the accompanying pH change causes healthy cerebral arterioles to dilate, subsequently increasing conductance and CBF (Hoiland et al., 2019)

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Unlike oral glutathione, which is rapidly degraded in the digestive tract, IV delivery avoids digestive degradation and results in essentially 100% absorption

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These differences may be related to different concentrations of berberine and different models of nerve injury