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The precise mechanisms underlying nonimmune-mediated idiosyncratic drug-induced liver injury (DILI) remain unclear

The -cyano amide-based Michael acceptors have also been elegantly used by the Taunton group as warheads in small-molecule inhibitors to react with active site cysteines while being minimally affected by the high concentration of intracellular GSH due to the fast reaction kinetics and the mM of K d (refs 31, 32)

Unfortunately, all the four patients on trial treatment died of illness consistent with EVD (Sweiti et al., 2017)

The Perceived Stress Scale (PSS) (171) is a widely used 10-item scale assessing the degree of appraisal of life situations as unpredictable and beyond control causing additional burden to an individual