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Collectively, these findings suggest that metformin may alleviate H 2 O 2 -induced oxidative damage, ameliorate chondrocyte apoptosis, and protect against ECM degeneration

This system-wide dysfunction in mice fed with choline-deficient choline was observed in the circulation, as it modulates plasma proteins associated with inflammation, immune response, and metabolic processes, including insulin metabolism, mitochondrial function, inflammation, and fructose metabolic processing (163)

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